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if oxygen is used up, it turns brown (because of the presence of metmyoglobin) or green (indicating spoilage from microbial action). Reducing enzymes, or chemical reactions with a reducing agent like ascorbate, reduce the Fe3+ to Fe2+. The NO formed from N2O3 can bind to the myoglobin (Fe2+) and form a heat-stable NO-myoglobin. Oximyoglobin is not heat stable and dissociates. The meat turns grey or brown. Oxygen, carbon monoxide (CO), and NO are biatomic molecules. Like NO, CO binds to myoglobin very tightly. In some countries, MAP packaging of fresh meat with 1 2% CO is permitted. CO and NO addition to fresh meat are not permitted in the EU. The CO-myoglobin and the NO-myoglobin are heat stable. Heating denatures the protein moiety, but the red NO-porphyrin ring system (often called nitroso-hemochromogen) still exists and is found in meat products heated to 120 C. This heat-stable red color will change after bacterial spoilage, and it fades under UV light. The rst is advantageous, since it allows the consumer to recognize spoilage, as fresh meat also changes color when it spoils. CO bound to myoglobin is light resistant. In the last two years the riddle of the red color of cured raw hams, like Parma ham produced without nitrite or nitrate, has been solved. Various authors have proved that the Fe2+ in the porphyrin ring is exchanged with Zn2+, which gives the hams a pleasant red color. Nitrite addition prevents the exchange (M ller et al. 2003; Parolari et al. 2003; Wakamatsu et al. 2004a, b; Adamsen et al. 2006).

Vermeirssen, V., J. V. Camp, and W. Verstraete. 2004. Bioavailability of angiotensin I converting enzyme inhibitory peptide (review article). British Journal of Nutrition 92:357 366. Watkins, B. A., and L. Yong. 2001. Conjugated linoleic acid: The present state of knowledge. In Handbook of Nutraceuticals and Functional Foods. Boca Raton, Fla.: CRC Press. Williams, P. G. 2007. Nutritional composition of red meat. Nutrition and Dietetics 64(supplement 4): S113 S119. Xu, S., T. D. Boylston, and B. A. Glatz. 2005. Conjugated linoleic acid content and organoleptic attributes of

1. 2. 3. Thomas Bayes, Essay towards solving a problem in the doctrine of chances, Philosophical Transactions of the Royal Society of London, 1763. Tom Mitchell, Machine Learning, WCB McGraw-Hill, Boston, 1997. Churn data set, in C. L. Blake, and C. J. Merz, UCI Repository of Machine Learning Databases, http://www.ics.uci.edu/ mlearn/MLRepository.html, University of California, Department of Information and Computer Science, Irvine, CA, 1998. Also available at the book series Web site. Daniel Larose, Discovering Knowledge in Data: An Introduction to Data Mining, Wiley, Hoboken, NJ, 2005. David Hand, Heiki Mannila, and Padhraic Smyth, Principles of Data Mining, MIT Press, Cambridge, MA, 2001. Stuart Russell, John Binder, Daphne Koller, and Keiji Kanazawa, Local learning in probabilistic networks with hidden variables, in Proceedings of the 14th International Joint Conference on Arti cial Intelligence, pp. 1146 1152, Morgan Kaufmann, San Francisco, CA, 1995. Peter Sprites, Clark Glymour, and Richard Scheines, Causation, Prediction, and Search, Springer-Verlag, New York, 1993. Marco Ramoni and Paola Sebastiani, Bayesian methods, in Michael Berthold and David J. Hand, ed., Intelligent Data Analysis, Springer-Verlag, Berlin, 1999. Breast cancer data set, compiled by Dr. William H. Wohlberg, University of Wisconsin Hospitals, Madison, WI; cited in O. L. Mangasarian and W. H. Wohlberg, Cancer diagnosis via linear programming, SIAM News, Vol. 23, No. 5, September 1990.

Current major theories of personality disorder vary in terms of their assessment of DSM Axis II. Benjamin s (1996a, 1996b) interpersonal theory based on Structural Analysis of Social Behavior (SASB) and Beck s cognitive theory (Beck & Freedman, 1990; Pretzer & Beck, 1996) both generally accept the DSM classification. Contemporary psychodynamic theories (e.g., Kernberg, 1984, 1996; McWilliams, 1994) and neurobiological theories (e.g., Depue, 1996; Paris, 2000) tend to ignore DSM classification in favor of current or future alternatives. Millon s (1990) evolutionary theory tends to parallel the DSM (Millon & Davis, 1996), although he is clear about DSM s limitations (Millon, 2000). Almost all of the recent practical-empirical literature concludes that the DSM system needs revision, although suggestions differ in terms of whether to focus revisions on the structure of the DSM (e.g., Axis I versus Axis II distinctions, categorical versus dimensional versus prototypal classification) or to focus revisions on the nature and scope of diagnostic criteria, or both.

Werch, C. E., Moore, M., DiClemente, C. C., Owen, D. M., Jobli, E., & Bledsoe, R. (2003). A sport-based intervention for preventing alcohol use and promoting physical activity among adolescents. Journal of School Health, 73, 380 388. Whiteside, S. P., & Lynam, D. R. (2001). The five factor model and impulsivity: Using a structural model of personality to understand impulsivity. Personality and Individual Dif ferences, 30, 669 689. Wichstrom, L., & Pedersen, W. (2001). Use of anabolic-androgenic steroids in adolescence: Winning, looking good or being bad Journal of Studies on Alcohol, 62, 5 14. Wilson, G. S., Pritchard, M. E., & Schaffer, J. (2004). Athletic status and drinking behavior in college students: The influence of gender and coping styles. Journal of American College Health, 52, 269 273. Wolff, C. (1985, November 12). Alcohol level cited in Lindbergh crash. New York Times, p. B7. Wulf, S. (1988, October 3). Dropping weights. Sports Illustrated, 69, 18. Yesalis, C. E., Kennedy, N. J., Kopstein, A. N., & Bahrke, M. S. (1993). Anabolic-androgenic steroid use in the United States. Journal of the American Medical Association, 270, 1217 1221.