winforms data matrix

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A shortened time to market can be worth hundreds of millions of dollars by extending the time a drug is on the market before the patent protection expires, and a Phase IV recall can be nancially devastating, even for a multinational pharmaceutical company One approach to decreasing development time is to use rational drug design, in which the drug discovery and screening phases of the drug de velopment process are compressed to months instead of years Instead of randomly hunting for drugs that may affect a speci c type of cancer cell, for example, researchers use computer modeling to determine the molecu lar structure of the drug that will most likely interfere with the metabo lism of the cancer Once the structure of the needed drug is determined, the drug can be synthesized in the laboratory.

The QuickBooks Navigator is a visual alternative to the standard Windowsbased menus. But it is more than a pretty face. The Navigator affords fast and powerful access to every feature of QuickBooks by logically grouping Activity icons in the upper left section of each of the ve different screens. These icons correspond to key areas of the program and accounting functions. You can access the ve Navigator screens from the start-up screen or from any point in the program by clicking the Navigator button from any screen. The following is a discussion of the ve different Navigator screens, all of which you will want to become familiar with.

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If you are active in the daily management of your business, it is likely that you will start with the Company Navigator screen each time you open QuickBooks, and you will probably visit it at least once each business day. This Company Navigator screen, shown in Figure 2-3, offers an overview of your company s performance and accounting system as a whole. It facilitates dayto-day operational management of your company by allowing you to access reports, budgets, your Chart of Accounts, reminders, backups, to-do lists, and scheduled shipping information from the same screen. The Company Navigator is divided into four sections: Icons in the upper left corner allow you to access critical management information. With a single click, you can view your daily to-do list and reminders, ship orders, or review budgets and cash ow. You can also make changes to your Chart of Accounts from this section of the Company Navigator screen. Reminders appear directly below the icons, with hypertext links that assist you in carrying out the referenced tasks. For example, as shown in Figure 2-4, the user is able to click on Overdue Invoices under the Bills to Pay Reminder to access a list of invoices. From there, he or she can click a particular invoice link in order to view and act on it.

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An alternate approach, combinatorial drug design, relies on biotech methods to quickly and inex pensively create expansive libraries of novel synthetic compounds that serve as candidate drugs It s important to note that while these technolo gies may eventually shorten the screening time from a year or more to days or weeks, there aren t yet any well-known drugs on the market that owe their existence to combinatorial chemistry or rational drug design There are, however, several drugs developed using these technologies while they were coming to market A challenge for the pharmaceutical industry is to develop rational and combinatorial drug design to the point that the return on investment in computer modeling software and hardware and in creating and maintain ing libraries of candidate drugs are economically viable alternatives to tra ditional approaches.

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Figure 2-3: The Company Navigator screen is a convenient management tool that is divided into four parts.

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The pressure on pharmaceutical rms to develop new approaches to drug development is enormous, given that the number of drugs on patent is shrinking, as is number of new applications to the FDA for regulatory approval Furthermore, although research and development expenditures have increased several-fold since the early 1980s, the number of drugs approved for the market hasn t increased in proportion to the in vestment Proponents of the biotech industry contend that the best way for the pharmaceutical industry to survive and thrive is to industrialize molec ular biology through computer and mass production technologies..

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